The CU School of Dental Medicine Office of Research Services offers faculty research support services that include preparation and submission of grant and contract applications, budget preparation, post award financial oversight, advising researchers of funding program changes, regulatory guidelines, requirements, policies and more.
Data Management and Sharing (DMS) Information and Guidance
Drs. Trevor Williams and Hong Li were awarded a five-year grant of nearly $2.2 million from NIDCR entitled “In utero rescue of cleft lip and palate in a humanized mouse model”. Williams and Li have formed a collaboration with Dr. Jennifer Matsuda at National Jewish Hospital to explore the potential for treating pre-natal treatment to prevent common facial birth defects such as orofacial clefting.
Dr. Katherine Fantauzzo’s NIDCR funded project for over $2.35 million entitled “Srsf3-mediated alternative RNA splicing in craniofacial development” was recently awarded. The major goals of this project are to provide significant insight to mechanisms underlying gene expression regulation during mammalian craniofacial development and new therapeutic directions for the treatment of human craniofacial birth defects.
Effective January 1, 2023, the salary limitation for Executive Level II is $212,100.
New FORMS-H Package for are now required for grant applications beginning January 25, 2023.
A key change in FORMS-H is the implementation of the 2023 NIH Data Management Sharing Policy. The new policy requires all grant submissions to outline how scientific data and any accompanying metadata will be managed and shared, taking into account any potential restrictions and limitations. Additionally, costs associated with the implementation of the revised Data Management Sharing Plans can now itemized in grant budgets. More details can be found at: https://sharing.nih.gov/data-management-and-sharing-policy/planning-and-budgeting-for-data-management-and-sharing.
Dr. Tamanna Tiwari received a one-year award from the State of Colorado Department of Public Health and Environment (CDPHE) for $37,800. She will be collaborating with CDPHE’s Oral Health Unit in the evaluation of School-Based Health Centers (SBHC) in Colorado. The study seeks to identify best practices of SBHCs through the evaluation of common operations, successes and challenges SBHCs encounter during the implementation of oral health programs. The overall evaluation will help to better understand the needs for resources and assistance of Colorado’s oral health programs.
Data Management and Sharing Policy (DMS): Effective January 25, 2023, NIH submissions will require a DMS.
DMS applies to all research funded or conducted in whole or in part by NIH that results in the generation of “scientific data.” Scientific data are defined as: “recorded factual material commonly accepted in the scientific community as of sufficient quality to validate and replicate research findings, regardless whether the data are used to support scholarly applications.”
Dr. Tamanna Tiwari received a $115,000 supplement award for her current National Institute of Dental and Craniofacial Research R03 grant entitled “Assessing completeness and accuracy of the EHRs harbored at BigMouth Dental Data Repository.” The additional funding will focus on exploring new methods and strategies to improve the usability of Electronic Health Record (EHR) data for the purpose of oral health research, dental education and patient care.
Dr. Katherine Chin will be collaborating with Dr. Vanessa Fabrizio in the School of Medicine, Pediatrics. The new award is funded by Cincinnati Children’s Hospital Medical Center entitled “Reduction of bloodstream infections from oral organisms in pediatric stem cell transplant: a randomized multicenter double-blind placebo-controlled study evaluating twice daily oral xylitol.” The study is being conducted at three institutions to evaluate the effectiveness of intraoral xylitol-wipe applications in reducing bloodstream infections among pediatric stem cell transplant patients.
Ms. Abigail Mumme-Monheit was awarded a Science Foundation Graduate Research Fellowships (NSF GRF). The NSF GRF four-year award of $184,000 provides a yearly stipend, tuition, benefits and fees. The purpose of the program is to broaden the participation in science and engineering of underrepresented groups, including women, minorities, persons with disabilities and veterans.
Puranik CP, Greany T, de Peralta T. Colorado innovation in simulation model in pediatric dentistry preclinical course. J Dent Educ. 2022 Dec;86 Suppl 3:1760-1762. doi: 10.1002/jdd.12886. Epub 2022 Jan 28.PMID: 35060619.
Labrie D, Price RB, Sullivan B, Salazar AM, Gautam D, Stansbury JW, Ferracane JL. Effect of thickness on the degree of conversion of two bulk-fill and one conventional posterior resin-based composites at high irradiance and high temporal resolution. Journal of the Mechanical Behavior of Biomedical Materials 2022 Oct;136:105489. doi: 10.1016/j.jmbbm.2022.105489. PMID: 36206689.
Weatherspoon DJ, Dye BA. Firmly establishing oral health care professionals' roles as vaccinators within the health care system. J Am Dent Assoc. 2022 Oct;153(10):925-928. doi: 10.1016/j.adaj.2022.07.001. Epub 2022 Aug 18. PubMed PMID: 35985882; PubMed Central PMCID: PMC9385764.
De Souza GM, Tiwari T, Fox CH, Miguez PA, Letra A, Geisinger ML, Patel M, Shaddox L, Ioannidou E. Perception of COVID-19 pandemic restrictions on dental researchers. J Dent Educ. 2022 Sep 21; doi: 10.1002/jdd.13104. PubMed PMID: 36131372; PubMed Central PMCID: PMC9538829.
McLeod CD, Kornegay EC, Tiwari T, Mason MR, Mathews RB, Apostolon DN, Heaton LJ, Wright JT, Quinonez RB. Pre-doctoral dental faculty perceptions toward value-based care: An exploratory study. J Dent Educ. 2022 Sep 21;. doi: 10.1002/jdd.13110. [Epub ahead of print] PubMed PMID: 36131371.
Raisa Bailon-Zambrano, Juliana Sucharov, Abigail Mumme-Monheit, Matthew Murry, Amanda Stenzel, Anthony T Pulvino, Jennyfer M Mitchell, Kathryn L Colborn, James T Nichols. Variable paralog expression underlies phenotype variation. eLife 2022 Sep;11:e79247. doi: 10.7554/eLife.79247.
Rogers MA, Campaña MB, Long R, Fantauzzo KA. PDGFR dimer-specific activation, trafficking and downstream signaling dynamics. J Cell Sci. 2022 Sep 1;135(17). doi: 10.1242/jcs.259686. Epub 2022 Sep 7. PubMed PMID: 35946433; PubMed Central PMCID: PMC9482349.
Patodia C, Sutton A, Gozalo D, Font K. Cost and complications associated with implant-supported overdentures with a resilient-attachment system: A retrospective study. J Prosthet Dent. 2022 Aug;128(2):181-186. doi: 10.1016/j.prosdent.2020.11.040. Epub 2021 Feb 6.PMID: 33563468.
Desvignes T, Robbins AE, Carey AZ, Bailon-Zambrano R, Nichols JT, Postlethwait JH, Stankunas K. Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Dev Dyn. 2022 Aug;251(8):1306-1321. doi: 10.1002/dvdy.475. Epub 2022 Apr 22. PubMed PMID: 35403297; PubMed Central PMCID: PMC9357109.
J Biol Chem. 2022 Aug;298(8):102194. doi: 10.1016/j.jbc.2022.102194. Epub 2022 Jun 24. PMID: 35760100.
Tiwari T, Tranby E, Thakkar-Samtani M, Frantsve-Hawley J. Determinants of Tooth Loss in a Medicaid Adult Population. JDR Clin Trans Res. 2022 Jul;7(3):289-297. doi: 10.1177/23800844211022277. Epub 2021 Jul 16. PubMed PMID: 34269110.
Dye BA, D'Souza RN, Albino J. Facing the future and deciding what we want oral health to become. J Am Dent Assoc. 2022 Jul;153(7):593-595. doi: 10.1016/j.adaj.2022.03.011. Epub 2022 May 25. PubMed PMID: 35643535; PubMed Central PMCID: PMC9130679.
Tiwari T, Maliq NN, Rai N, Holtzmann J, Yates L, Diep V, Tranby EP, Frantsve-Hawley J. Evaluating Trust in the Patient-Dentist Relationship: A Mixed-Method Study. JDR Clin Trans Res. 2022 Apr 16;:23800844221087592. doi: 10.1177/23800844221087592. [Epub ahead of print] PubMed PMID: 35430916.
Stanley M. Kanai, Caleb Heffner, Timothy C. Cox, Michael L. Cunningham, Francisco A. Perez, Aaron M. Bauer, Philip Reigan, Cristan Carter, Stephen A. Murray, David E. Clouthier. Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants. Dis Model Mech. 2022 Apr 1; 15(4): dmm049320. Published online 2022 Apr 29. doi: 10.1242/dmm.049320. PMCID: PMC9066496.
Rogers MA, Dennison BJC, Fantauzzo KA. Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis. J Vis Exp. 2022 Apr 1;(182). doi: 10.3791/63834. PubMed PMID: 35435918; PubMed Central PMCID: PMC9093641.
Herman L, Font K, Soldatos N, Chandrasekaran S, Powell C. The Surgical Anatomy of the Greater Palatine Artery: A Human Cadaver Study. Int J Periodontics Restorative Dent. 2022 Mar-Apr;42(2):233-241. doi: 10.11607/prd.4945.PMID: 35353093.
Van Otterloo E, Milanda I, Pike H, Thompson JA, Li H, Jones KL, Williams T. AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development. Elife. 2022 Mar 25;11. doi: 10.7554/eLife.70511. PubMed PMID: 35333176; PubMed Central PMCID: PMC9038197.
Sharp IG, Minick G, Carey C, Shellhart CW, Tilliss T. Assessment of simulated vs actual orthodontic tooth movement with a customized fixed lingual appliance using untreated posterior teeth for registration and digital superimposition: A retrospective study. Am J Orthod Dentofacial Orthop. 2022 Feb;161(2):272-280. doi: 10.1016/j.ajodo.2021.02.018.PMID: 35094752.
Shull LC, Lencer ES, Kim HM, Goyama S, Kurokawa M, Costello JC, Jones K, Artinger KB. PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development. 2022 Feb 15;149(4). doi: 10.1242/dev.200082. Epub 2022 Feb 24. PubMed PMID: 35132438; PubMed Central PMCID: PMC8918787.
Trivedi R, Gautam D, Kehe GM, Escobedo HD, Patel K, Stansbury JW, Schurr MJ, Nair DP. Synthesis, characterization and evaluation of azobenzene nanogels for their antibacterial properties in adhesive dentistry. Eur J Oral Sci. 2022 Feb;130(1):e12832. doi: 10.1111/eos.12832. Epub 2021 Dec 19.PMID: 34923692.
Taiyab A, Akula M, Dham J, Deschamps P, Sheardown H, Williams T, Borrás T, West-Mays JA. Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes. J Neurosci Res. 2022 Feb;100(2):638-652. doi: 10.1002/jnr.24982. Epub 2021 Nov 25. PubMed PMID: 34822722; PubMed Central PMCID: PMC8961273.
Bhatia S, Nguyen D, Darragh LB, Van Court B, Sharma J, Knitz MW, Piper M, Bukkapatnam S,
Gadwa J, Bickett TE, Bhuvane S, Corbo S, Wu B, Lee Y, Fujita M, Joshi M, Heasley LE, Ferris RL, Rodriguez O, Albanese C, Kapoor M, Pasquale EB, Karam SD. (2022) EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment. Nat Commun. 13(1):3535. PMC9209511.